Valor adaptativo de la hiperbilirrubinemia en neonatos

We have shown in an in-vitro study utilising neonatally-derived blood culture isolates that bilirubin may have antibacterial properties against GBS We had previously reported that bilirubin had no effect on bacterial growth in Gram-negative E. coli clinical strains when compared to GBS strains23 Hyperbilirubinemia is a recognised feature of sepsis in neonatal, paediatric and adult populations and indeed there is evidence to suggest that haem catabolism is increased in the critically ill with a resultant rise in serum bilirubin25 Bilirubin may have an under-recognised antibacterial role of potential importance in neonatal sepsis Links Jaundice in newborns could be an evolutionary safeguard against death from sepsis http://theconversation.com/jaundice-in-newborns-could-be-an-evolutionary-safeguard-against-death-from-sepsis-97049 Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin https://www.nature.com/articles/s41598-018-24811-3 Kadl, A., Pontiller, J., Exner, M. & Leitinger, N. Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock. 28, 582–588 (2007). Goddard, M. et al. Bilirubin has anti-bacterial properties against Gram-positive bacteria: A potential benefit of physiological jaundice? Gastroenterology. 140, S941 (2011).